ERS Respiratory Digests

Staying up-to-date with evidence-based medical research is crucial and effective learning is key when time is limited.

ERS understands this can be challenging for busy health professionals, therefore ERS Respiratory Digests was created to help you keep up with the latest advances in respiratory medicine.

Experts regularly post updates on recent publications and hot topics, and ERS encourages you to have your say about the topics posted on this page by leaving comments below each summary.

COVID-19

Emer Kelly, Incoming…

Digest Author(s): Emer Kelly

Outcome of Hospitalisation for COVID-19 in Patients with Interstitial Lung Disease: An International…

Author(s): Thomas M Drake, Annemarie B. Docherty, Ewen M…

Am J Respir Crit Care Med 2020; 202: 1656-1665

The impact of COVID-19 on patients with Interstitial Lung Disease (ILD) was studied in this international multicentre audit. Outcomes in…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

6-month consequences of COVID-19 in patients discharged from hospital: a cohort study

Author(s): Huang C, Huang L, Wang Y et al

Lancet January 08, 2021

COVID -19 pandemic resulted in more than 89 million cases and 1.9 million deaths. The long term consequences of SARS-2-COV infection remain…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

Author(s): Baden LR, El Sahly HM, Essink B et al.

NEJM December 30, 2020

COVID-19 pandemic affected millions of people worldwide. We are currently facing the vaccine era. We need effective and safe vaccines for the…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers

Author(s): Lumley SF, O’Donnell D, Stoesser Ne et al

NEJM December 23, 2020

The vast majority of people infected with SARS-CoV-2 develop antibodies, however, the exact time that these antibodies protect the person from a…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

Author(s): Polack FP, Thomas SJ,Kitchin N et al.

NEJM December 10, 2020

On December 10, 2020, Fernando Polack et al published a study in NEJM where they evaluated the safety and efficacy of the BNT162b2 vaccine.…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Patient outcomes after hospitalisation with COVID-19 and implications for follow-up: results from a…

Author(s): Arnold DT, Hamilton FW, Milne A, et al

Thorax 3 Dec 2020

After being treated for COVID-19 related pneumonia and discharged from the hospital, patients have to adapt their life on a different…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia

Author(s): Simonovich VA, Burgos Pratx LD, Scibona P et al

NEJM November 24, 2020

COVID-19 infenction is still lacking effective and ideal treatment. In the current study, the authors randomly assigned hospitalized adult…
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COVID-19

Journal article

Digest Author(s): Emer Kelly, Incoming e-Learning Director

Aerosol generation from the respiratory tract with various modes of oxygen delivery

Author(s): Nathaniel T. Gaeckle, Jihyeon Lee, Yensil Park et…

Am J Respir Crit Care Med 2020 Oct 15; 202: 1115-1124

There has been increased use of high-flow nasal cannula (HFNC) and non invasive ventilation (NIPPV) in the era of COVID-19 and in particular the…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young…

Author(s): Ramasamy MN, Minassian AM, Ewer KJ et al .

Lancet Published Online November 19, 2020

The current study is a single-blind, randomised, controlled, phase 2/3 trial. The study population consisted of healthy adults aged 18 years and…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2…

Author(s): Monk PD, Marsden RJ, Tear VJ et al.

Lancet November12, 2020

SARS COV 2 infection is characterized by a wide spectrum of clinical manifestations ranging from asymptomatic or/and mild disease to severe and…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

SARS-CoV-2 seroprevalence and transmission risk factors among high-risk close contacts: a…

Author(s): Tek Ng O, Marimuthu K, Koh V et al

Lancet Infect Dis 2020

We are currently facing the second wave of SARS-COV 2 pandemic. Almost 50.000.000 cases were reported with approximately 1.250.000 deaths. The…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

SARS-CoV-2 seroprevalence and asymptomatic viral carriage in healthcare workers: a cross-sectional…

Author(s): Shields A, Faustini SE, Perez-Toledo M et al.

Thorax 2020; 11 September 2020

Healthcare workers are susceptible to SARS-COV-2 infection. Previously published data supports increased infection rates either in symptomatic…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Effect of Hydroxychloroquine in Hospitalized Patients with Covid-19

Author(s): The RECOVERY Collaborative Group

NEJM October 8, 2020

In the initial phase of COVID-19 infection both Hydroxychloroquine and chloroquine, two old drugs with multiple indications were used as a…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Remdesivir for the Treatment of Covid-19 — Final Report

Author(s): Beigel JH, Tomashek KM, Dodd LE et al

NEJM October 8, 2020

COVID-19 infection is lacking efficacious treatment at the moment. Many therapeutic approaches are still on development while some others,…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Humoral Immune Response to SARS-CoV-2 in Iceland

Author(s): Gudbjartsson DF, Norddahl GL, Melsted P, et al

NEJM September 1, 2020

Several published studies reported that the antibodies produced by our immune system against the new coronavirus were rapidly declining in either…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Saliva or Nasopharyngeal Swab Specimens for Detection of SARS-CoV-2

Author(s): Wyllie AL, Fournier J, Casanovas-Massana A, et…

NEJM August 28, 2020

The emergence and spread of 2019 novel coronavirus disease (COVID-19) and the associated acute respiratory distress syndrome (ARDS) are causing a…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate…

Author(s): Spinner CD, Gottlieb RL, Criner GJ et al

JAMA. Published online August 21 2020

As of August 10, 2020, coronavirus disease 2019 (COVID-19), the disease caused by SARS-CoV-2, resulted in more than 730 000 deaths worldwide.…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

Author(s): The RECOVERY Collaborative Group

N Engl J Med July 17, 2020

Treatment for Covid-19 severe diseases still remains a controversial issue. The absence of reliable evidence from well designed randomized…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and…

Author(s): Ling Li, Wei Zhang, Yu Hu et al

JAMA. Published online June 3, 2020

This is the first randomized plasma-based clinical trial of COVID-19 patients. This study is notable for the fact that it used a randomized study…
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COVID-19

Review

Digest Author(s): Stylianos Loukides, e-Learning Director

Prevalence of Asymptomatic SARS-CoV-2 Infection

Author(s): Oran DP and Topol DJ.

Annals of Internal Medicine 3rd June 2020

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly throughout the world since the first cases of coronavirus disease…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a…

Author(s): Mehra MR, Desai SS, Ruschitzka F et al

Lancet 22 May 2020

Considering the current therapeutic strategies against COVID-19, the combination Hydroxychloroquine or chloroquine with macrolide is recommended.…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Severe Covid-19

Author(s): Berlin DA, Gulick RM, Martinez FJ

N Engl J Med. 2020 May 15

Severe coronavirus disease 2019 (Covid-19) typically begins after 1 week after the clinical onset of the disease. It is usually characterized by…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19

Author(s): Geleris J, Sun Y, Platt J et al

N Engl J Med. 2020 May 7

Chloroquine and hydroxychloroquine are widely used in the treatment of malaria and rheumatic diseases. Hypothetically, they have been suggested…
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COVID-19

Review

Digest Author(s): Antonogiannaki Elvira-Markela, MD, PhD

COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic…

Author(s): Bikdeli B, Madhavan MV, Jimenez D et al

J Am Coll Cardiol. 2020 Apr 15

Preliminary reports suggest that hemostatic abnormalities, including disseminated intravascular coagulation (DIC), occur in patients affected by…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With…

Author(s): Richardson S, Hirsch S, Narasimhan M et al

JAMA. Published online April 22, 2020.…

The first confirmed case of coronavirus disease 2019 (COVID-19) in the US was reported from Washington State on January 31, 2020. In New York…
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COVID-19

Correspondence

Digest Author(s): Stylianos Loukides, e-Learning Director

Clinical Characteristics of Covid-19 in New York City

Author(s): Goyal P, Choi JJ, Pinheiro LC et al

N Engl J Med. 2020, Apr 17

In this study, data obtained from USA patients with COVID-19 infection, is presented. Data was obtained between March 5 and March 27, 2020. Data…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Compassionate Use of Remdesivir for Patients with Severe Covid-19

Author(s): Grein J, Ohmagari N, Shin D et al

NEJM April 10, 2020

Infection with SARS COV-2 has become a worldwide pandemic. Clinical manifestations of the disease are quite variable. We have asymptomatic…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19

Author(s): Vaduganathan M, Vardeny O, Michel T et al

NEJM March 30, 2020

The renin–angiotensin–aldosterone system (RAAS) is an elegant cascade of vasoactive peptides that orchestrate key processes in human…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

The effect of control strategies to reduce social mixing on outcomes of the COVID-19 epidemic in…

Author(s): Prem K, Liu Y, Russell TW et al

Lancet Public Health 2020, Published Online March 25, 2020

In December, 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus, emerged in Wuhan, China. The COVID-19…
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COVID-19

Journal article

Digest Author(s): Argyris Tzouvelekis, MD

Critical Care Utilization for the COVID-19 Outbreak in Lombardy, Italy

Author(s): Grasselli G, Pesenti A, Cecconi M.

JAMA. Published online March 13, 2020.…

The world has set its eyes on the pandemic crisis of COVID-19. In an elegant commentary recently published in JAMA, authors report the reaction…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a…

Author(s): Zhou F, Yu T, Du R, et al

Lancet Published Online March 9, 2020

Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore

Author(s): Young BE, Xiang Ong SW, Kalimuddin S et al

JAMA. Published online March 03, 2020.…

The authors wanted to report the Singapore experience in regard to SARS CoV-2 infection in Singapore. Epidemiological and clinical data is…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Clinical Characteristics of Coronavirus Disease 2019 in China

Author(s): Guan W, Ni Z, Hu Y et al

NEJM 2020; 10.1056/NEJMoa2002032

This is the first big study which describes the clinical characteristics of coronovirus disease in China. The authors retrieved data from medical…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in…

Author(s): Chen N, Zhou M, Dong X et al

Lancet 2020; 395: 507–13

In December, 2019, a pneumonia associated with the 2019 novel coronavirus (2019-nCoV) emerged in Wuhan, China. This retrospective study aimed to…
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