Clinical Research Collaborations (CRCs) at the ERS Congress

In total, an impressive 85 abstracts featuring representatives from ERS-supported Clinical Research Collaborations (CRCs) will be presented at the ERS Congress 2024 through a combination of oral and poster presentations.

Read more about the 13 abstracts highlighted by featured CRCs below.

Learn more about ongoing CRCs

The call for the Clinical Research Collaboration: application programme is now open

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Healthcare worker views on antimicrobial resistance in chronic respiratory disease

Background: Background: Antimicrobial resistance (AMR) in chronic respiratory disease is a global crisis. However, little is known regarding the specific challenges faced by healthcare workers across the world in this area.

Aims: To survey healthcare workers globally regarding the burden of AMR in chronic respiratory disease and challenges in the implementation of antimicrobial stewardship programmes in their regions.

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Learn more about AMR-Lung.

The international registry for primary ciliary dyskinesia reveals regional variation of genotypes and significant genotype-phenotype correlations

Background: Primary ciliary dyskinesia (PCD, ORPHA:244) is a rare, clinically and genetically heterogeneous group of diseases characterised by deficient mucociliary clearance of the airways.

Aims: Our aim was to characterize the underlying genetic defects, assess the geographic distribution and investigate the global impact of genotypes on clinical aspects of the disease, focusing on lung function and laterality defects.

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Learn more about the BEAT-PCD CRC.

Airflow limitation among young adults in Europe: A preliminary analysis in a Chronic Airway Diseases Early Stratification (CADSET) collaboration including 109 216 individuals across seven population-based cohorts

Background: The extent to which airflow limitation, a key feature of chronic obstructive pulmonary disease (COPD) presenting later in life, is already present in early adulthood is unclear.

Aim: We investigated the prevalence of airflow limitation in young adults across European population-based cohorts.

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Learn more about CADSET.

Creating Child-BEAR-Net’s international paediatric bronchiectasis registry: an ERS CRC initiative

Background: Multi-country disease registries are important for providing real-world data, as shown by the EMBARC registry for the European adult population with bronchiectasis (BE).

Aims: Lacking comparable paediatric data, an objective of Child-BEAR-Net was to create an international paediatric BE registry. However, the governance and ethics approvals needed for international registries are cumbersome.

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Learn more about Child-BEAR-Net.

School-entry health assessment of children previously diagnosed with neuroendocrine hyperplasia of infancy. CRC ChILD-EU

Background: Neuroendocrine hyperplasia of infancy (NEHI) is a form of childhood interstitial lung disease. Clinical improvement is observed over time; however, follow-up data are relatively scarce.

Aim: This study aimed to evaluate NEHI patients (pts) at school-entry age.

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Learn more about ChILD-EU CRC.

Impact of digital health on the patient-provider relationship in respiratory secondary care settings: a mixed methods systematic review from IHI DRAGON/CONNECT CRC

Introduction: Patients and providers have expressed concerns about how digital care affects their relationship. We systematically reviewed the evidence on how digital health affects the patient-provider relationship.

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Learn more about CONNECT CRC.

Gender-specific aspects of alpha-1-antitrypsin deficiency in relation to lung and liver disease, symptom burden and exacerbations: Data from the EARCO registry

Background: Gender affects many aspects of chronic obstructive pulmonary disease (COPD). Limited data are available on gender issues in alpha-1 antitrypsin deficiency (AATD). We investigated gender issues in the EARCO registry, a prospective observational cohort study.

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Learn more about EARCO.

Highly symptomatic patients have an increased risk of exacerbations and benefit from long-term macrolide treatment in Bronchiectasis

Background: Prior exacerbations are the main risk factor for exacerbations in bronchiectasis. Guidelines recommend macrolide only in frequent exacerbators. Other studies suggest that symptoms are related to increased exacerbation risk.

Aim: To investigate if symptoms could independently predict future exacerbations and identify responders to long-term macrolide therapy.

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Learn more about EMBARC CRC.

A perspective on COVID-19 hospitalised patients across Europe: data from the END-COVID CRC

Background and aim: The COVID-19 pandemic has represented a relevant burden on European healthcare systems in the past few years. Differences in the hospitalised population features, treatment regimens and outcomes across European Countries are expected.

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Learn more about END-COVID CRC.

Effect of non-respiratory arousals on residual sleepiness in CPAP-treated OSA patients

Background and aim: To test the impact of the ratio of non-respiratory to total arousals (NRAR) at baseline polysomnography on residual sleepiness (RES) evolution in obstructive sleep apnea (OSA) patients treated with Continuous Positive Airway Pressure (CPAP).

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Learn more about ESADA CRC.

Characteristics of chronic cough patients across Europe: A descriptive analysis from the ERS NEUROCOUGH CRC Registry

Introduction and aims: The ERS N-EUROCOUGH CRC established the first Europe-wide chronic cough (CC) patient registry comprising clinical, physiological and biological data. Here we report a descriptive analysis of clinical characteristics at baseline and 12-month follow up.

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Learn more about N-EUROCOUGH CRC.

Management of Pulmonary Hypertension associated with Chronic Lung Disease: Results of the ERS Clinical Research Collaboration PHAROS survey

Introduction: Pulmonary hypertension associated with chronic lung diseases (PH-CLD) is an heterogenous group in terms of clinical presentation and management. Pooling data from registries could help to delineate different phenotypes.

Aim: This survey aimed to evaluate the management of PH-CLD across different European PH centers and to assess the feasibility of data registry integration.

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Learn more about PHAROS.

Initial data analysis of the SHARP CRC patient population reveals a large heterogeneity among European patients with severe asthma

Introduction and aims: The heterogeneity of patients with severe asthma in Europe necessitates real-world evidence from large cohorts to improve disease understanding and patient care. This study aims to address this gap.

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Learn more about SHARP.

Providing support to projects to help build and maintain European multi-centre networks of researchers

Clinical Research Collaborations (CRCs) are ERS-supported projects which bring together multiple stakeholders including clinical and translational researchers, radiologists, biostatisticians, associated funding partners, and patients to collaborate on an identified area within respiratory medicine.