Netherlands Amsterdam

Amsterdam University Medical Center, location VUMC (Department of Physiology)

Department of Physiology

Brief overview

The Department of Physiology at Amsterdam (University Medical Center, location VUMC within the Amsterdam Cardiovascular Sciences) studies (patho)mechanisms of the cardiopulmonary diseases such as pulmonary hypertension and heart failure. In our research, we aim to identify novel treatments using interdisciplinary approach.

Our mission is:
1. To prevent and reverse cardiopulmonary diseases at the highest standard of medical care
2. To develop and implement novel methods and techniques to advance our knowledge on cardiopulmonary diseases
3. To produce integrative medical research driven by both clinical and basic researchers
4. To teach and train under- and postgraduate students and PhD students

Research areas

Biomarkers/ Epigenetics/ Molecular biology/ Pulmonary hypertension

Host center eligibility

Global fellowships (return phase only)/European fellowships

Research infrastructure/facilities

1. Animal Research (Animal models of pulmonary hypertension and heart failure)
2. Ex vivo research (3D cell culture models, Thrombosis-on-Chip models, Engineered heart tissue models, human precision cut lung slices (hPCLSs) and human heart slices)
3. Clinical facilities (outpatient clinic, hospital ward, Medium Care, Intensive Care, imaging, pathology,
bacterology, virology, routine labs)
4. Cell biology and Medicinal Chemistry research (Pulmonary vascular cells, state of the art molecular
biological methods, state of the art immuno-histochemistry, computer aided drug design, Medicinal
chemistry, etc)

Research funding/resources

The host department and host lab have received national and international funding for research in cardiopulmonary diseases. Some key funding sources are: European Research Council (ERC) grant, investigator initiated research grants from big pharmaceutical companies, grants from the Lung Foundation Netherlands (Longfonds), and the Dutch Pulmonary Hypertension Society.

Links to non-academic sector

Several public-private partnership projects such as investigator initiated grants from big pharmaceutical companies.

Experience hosting international researchers, career development & training programmes, outreach activities

Our department hosted more than 10 international postdocs and currently hosting two postdocs. Our Graduate School organises 32 courses for PhD’s and Post-docs.

This includes:
1. General skills (e.g. lab safety, career development, project management)
2. Scientific methods (e.g. biostatistics, epidemiology, -omics methods)
3. Specific areas (e.g. infectious diseases, gene targeting, advanced immunology etc)

The course take 2-10 days and are running 2-6 times per year.

The Graduate School organized courses specifically focused on post-docs in: scientific project management, scientific career development (this includes intensive coaching), and entrepeneurship. The fellowship recipients will have an access to these courses that are part of the Graduate School. Furthermore, our department is part of Amsterdam Cardiovascular Sciences (ACS) and collaborates with Amsterdam Young Academy (AYA). Therefore, there are number of courses and trainings are available for the career development for postdocs.

HR Excellence in Research – EU award