To successfully treat tuberculosis it is an absolute necessity that the antimicrobial agents used reaches the site of infection in sufficient amounts. This is ensured by carefully selected doses, accounting for patient factors and potential interactions with co-administered compounds.
Educational aims
To understand the link between drug doses and treatment outcome, and the principal processes governing the relation.
Topics
- Why the dose matters – link to outcome
- The main pharmacokinetic processes (absorption, distribution, metabolism, elimination)
- Site-of-disease pharmacokinetics in pulmonary TB
- Combination treatment and drug-drug interactions
- The population approach – use of mathematical models
Target audience
- Healthcare Professionals
- Decision Makers
- Policy Makers
- Researchers
- TB Community
Format
The webinar will be divided into 2 parts:
- For the first 20 minutes, the speaker Elin Svensson will discuss the role of pharmacology in modern clinical studies of novel anti-tuberculosis trials.
- The second half of the webinar will be filled with an open discussion, moderated by Raquel Duarte and Christoph Lange, giving the opportunity to the participants of sharing perspectives on the topics presented and/or posing questions to the speaker.
Learning objectives
- Basic understanding for the processes that determines drug exposures
- The link between drug exposure and treatment outcome
- Specific challenges in combination therapy in anti-tuberculosis treatment
CME credit
An application for accreditation of this webinar has been made to the European Board for Accreditation in Pneumology (EBAP) for 1 CME credit per 1-hour attendance. If accredited, the CME credit will be granted upon attendance of at least 60 minutes during the live webinar only.
What is a webinar?
A webinar closely simulates a lecture-based teaching experience. The speaker can interact with the audience, just as in a classroom setting. During the webinar, you will be asked to share your opinion on issues related to the topic using interactive polls.
All participants will be able to hear the lecturer and see the slides throughout the presentation. As a participant you will be able to pose questions or discuss ideas with the other participants via the text chat facility and the speaker will respond to the questions via the microphone.
Login guidelines
More information will be communicated in due course.
- Please log in to the webinar 20 minutes before it is scheduled to commence. If you have any technical difficulties whilst trying to log in or during the session please contact e-learning@ersnet.org.
- Check Central European Time.
- To achieve the best quality, we recommend to avoid downloading anything from the internet during your connection to the lecture and stopping all other programmes.
- Please also ensure that your audio settings are not set to mute and adjust the volume to a comfortable level.
About UNITE4TB
UNITE4TB is a public-private partnership with representation from academic institutions, small- and medium-sized enterprises (SMEs), public organisations, and pharmaceutical companies. The 7-year, €185 million project aims to accelerate and improve the clinical evaluation of combinations of existing and novel drugs, with the goal of developing new and highly active Tuberculosis (TB) treatment regimens for drug-resistant and -sensitive TB. For more information, visit the consortium website: www.unite4TB.org
Funding
The UNITE4TB project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 101007873. The JU receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA, Deutsches Zentrum für Infektionsforschung e. V. (DZIF), and Ludwig-Maximilians-Universität München (LMU). EFPIA/AP contribute to 50% of funding, whereas the contribution of DZIF and the LMU University Hospital Munich has been granted by the German Federal Ministry of Education and Research. For further information: www.imi.europa.eu
Disclaimer
This communication reflects the author’s view. Neither IMI nor the European Union, EFPIA, or any Associated Partners are responsible for any use that may be made of the information contained herein.
