Although a lot of emphasis in research has been placed on genomic analyses, most biological processes are executed by proteins. The aggregate of protein expression and posttranslational modifications can be assessed by high-throughput proteomics. As such, proteomics is a powerful tool in understanding complex biological systems and it can shed light on the molecular mechanisms underlying disease pathogenesis and progression. Moreover, it can identify putative therapeutic targets, and proteomic signatures or components thereof can be used as disease biomarkers. There are various ways to perform proteomic analyses and it can be applied on a variety of clinical sample types.
Educational aims
- To understand the principles underlying high-throughput proteomic analyses and the various mass spectrometry platforms (what is analysed and how, what type of information is yielded) (this will not include in situ analyses as that will be a topic for a future webinar)
- To understand what sample types can be used for proteomic analyses, how samples should be collected and stored, and which controls should be included
- To receive insight into how analyses are performed, how to make sense of the data obtained, how to connect readouts to biological processes
- Examples will be provided based on key publications using proteomics to illustrate what type of questions can be addressed using this technology and how to critically review the technology in a paper
- Aspects of data sharing will be addressed
Topics
- Proteomics basic principles
- How to connect proteomic data to cellular processes
- How proteomics can help understand pathogenic processes in lung diseases
- How proteomic signatures can be used as disease biomarkers
Target audience:
- Clinicians
- Trainees
- Basic Translational scientists
- Bioinformatician
Format
This webinar will include a workshop with interactive quizzes, Q&A with audience, presentation of seminal papers and introduction to analysis workflows.
Learning outcomes
After following this webinar, participants should be able to:
- Understand the relevance of proteomics in disease characterization.
- Learn which steps are required to undertake and assess proteomics.
CME credit
An application for accreditation of this webinar has been made to the European Board for Accreditation in Pneumology (EBAP) for 1 CME credit per 1-hour attendance. If accredited, the CME credit will be granted upon attendance of at least 60 minutes during the live webinar only.
What is a webinar?
A webinar closely simulates a lecture-based teaching experience. The speaker can interact with the audience, just as in a classroom setting. During the webinar, you will be asked to share your opinion on issues related to the topic using interactive polls.
All participants will be able to hear the lecturer and see the slides throughout the presentation. As a participant you will be able to pose questions or discuss ideas with the other participants via the text chat facility and the speaker will respond to the questions via the microphone.
Login guidelines
More information will be communicated in due course.
- Please log in to the webinar 20 minutes before it is scheduled to commence. If you have any technical difficulties whilst trying to log in or during the session please contact e-learning@ersnet.org.
- Check Central European Time.
- To achieve the best quality, we recommend to avoid downloading anything from the internet during your connection to the lecture and stopping all other programmes.
- Please also ensure that your audio settings are not set to mute and adjust the volume to a comfortable level.
Diseases/methods:
- Airway diseases
- Interstitial lung diseases
- Paediatric respiratory diseases
- Pulmonary Vascular diseases
- Respiratory infections
- Thoracic oncology
Target audience
- Clinicians
- Trainees
- Basic Translational scientists
- Bioinformaticians