ERS Respiratory Digests

Staying up-to-date with evidence-based medical research is crucial and effective learning is key when time is limited.

ERS understands this can be challenging for busy health professionals, therefore ERS Respiratory Digests was created to help you keep up with the latest advances in respiratory medicine.

Experts regularly post updates on recent publications and hot topics, and ERS encourages you to have your say about the topics posted on this page by leaving comments below each summary.

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Randomized Trial of Nocturnal Oxygen in Chronic Obstructive Pulmonary Disease

Author(s): Lacasse Y, Sériès F, Corbeil F, et al

N Engl J Med 2020; 383:1129-1138

In the early 80s two trials provided scientific evidence, that the use of long-term oxygen therapy used for at least 15 to 18 hours per day…
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Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Inhaled Molgramostim Therapy in Autoimmune Pulmonary Alveolar Proteinosis

Author(s): Trapnell,ΒC, Inoue Y, Bonella F, et al

NEJM September 7, 2020

Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare disease characterized by progressive surfactant accumulation and hypoxemia. It is…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Humoral Immune Response to SARS-CoV-2 in Iceland

Author(s): Gudbjartsson DF, Norddahl GL, Melsted P, et al

NEJM September 1, 2020

Several published studies reported that the antibodies produced by our immune system against the new coronavirus were rapidly declining in either…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Saliva or Nasopharyngeal Swab Specimens for Detection of SARS-CoV-2

Author(s): Wyllie AL, Fournier J, Casanovas-Massana A, et…

NEJM August 28, 2020

The emergence and spread of 2019 novel coronavirus disease (COVID-19) and the associated acute respiratory distress syndrome (ARDS) are causing a…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate…

Author(s): Spinner CD, Gottlieb RL, Criner GJ et al

JAMA. Published online August 21 2020

As of August 10, 2020, coronavirus disease 2019 (COVID-19), the disease caused by SARS-CoV-2, resulted in more than 730 000 deaths worldwide.…
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Guideline

Digest Author(s): Stylianos Loukides, e-Learning Director

Diagnosis of Hypersensitivity Pneumonitis in Adults: An Official ATS/JRS/ALAT Clinical Practice…

Author(s): Raghu G, Remy-Jardin M, Ryerson CJ et al

Am J Respir Crit Care Med. 2020; 202: e36–e69

Hypersensitivity pneumonitis (HP) is an inflammatory and/or fibrotic disease affecting the lung parenchyma and small airways. It typically…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

Author(s): The RECOVERY Collaborative Group

N Engl J Med July 17, 2020

Treatment for Covid-19 severe diseases still remains a controversial issue. The absence of reliable evidence from well designed randomized…
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Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Triple Inhaled Therapy at Two Glucocorticoid Doses in Moderate-to-Very-Severe COPD: ETHOS study

Author(s): Rabe KF, Martinez FJ, Ferguson GT et al.

N Engl J Med 2020; 383: 35-48

The ETHOS study randomized 8509 patients in a 1:1:1:1 manner to receive twice-daily inhaled doses of triple therapy (inhaled glucocorticoid [320…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Effect of Convalescent Plasma Therapy on Time to Clinical Improvement in Patients With Severe and…

Author(s): Ling Li, Wei Zhang, Yu Hu et al

JAMA. Published online June 3, 2020

This is the first randomized plasma-based clinical trial of COVID-19 patients. This study is notable for the fact that it used a randomized study…
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COVID-19

Review

Digest Author(s): Stylianos Loukides, e-Learning Director

Prevalence of Asymptomatic SARS-CoV-2 Infection

Author(s): Oran DP and Topol DJ.

Annals of Internal Medicine 3rd June 2020

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly throughout the world since the first cases of coronavirus disease…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a…

Author(s): Mehra MR, Desai SS, Ruschitzka F et al

Lancet 22 May 2020

Considering the current therapeutic strategies against COVID-19, the combination Hydroxychloroquine or chloroquine with macrolide is recommended.…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Severe Covid-19

Author(s): Berlin DA, Gulick RM, Martinez FJ

N Engl J Med. 2020 May 15

Severe coronavirus disease 2019 (Covid-19) typically begins after 1 week after the clinical onset of the disease. It is usually characterized by…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19

Author(s): Geleris J, Sun Y, Platt J et al

N Engl J Med. 2020 May 7

Chloroquine and hydroxychloroquine are widely used in the treatment of malaria and rheumatic diseases. Hypothetically, they have been suggested…
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COVID-19

Review

Digest Author(s): Antonogiannaki Elvira-Markela, MD, PhD

COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic…

Author(s): Bikdeli B, Madhavan MV, Jimenez D et al

J Am Coll Cardiol. 2020 Apr 15

Preliminary reports suggest that hemostatic abnormalities, including disseminated intravascular coagulation (DIC), occur in patients affected by…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With…

Author(s): Richardson S, Hirsch S, Narasimhan M et al

JAMA. Published online April 22, 2020.…

The first confirmed case of coronavirus disease 2019 (COVID-19) in the US was reported from Washington State on January 31, 2020. In New York…
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COVID-19

Correspondence

Digest Author(s): Stylianos Loukides, e-Learning Director

Clinical Characteristics of Covid-19 in New York City

Author(s): Goyal P, Choi JJ, Pinheiro LC et al

N Engl J Med. 2020, Apr 17

In this study, data obtained from USA patients with COVID-19 infection, is presented. Data was obtained between March 5 and March 27, 2020. Data…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Compassionate Use of Remdesivir for Patients with Severe Covid-19

Author(s): Grein J, Ohmagari N, Shin D et al

NEJM April 10, 2020

Infection with SARS COV-2 has become a worldwide pandemic. Clinical manifestations of the disease are quite variable. We have asymptomatic…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19

Author(s): Vaduganathan M, Vardeny O, Michel T et al

NEJM March 30, 2020

The renin–angiotensin–aldosterone system (RAAS) is an elegant cascade of vasoactive peptides that orchestrate key processes in human…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

The effect of control strategies to reduce social mixing on outcomes of the COVID-19 epidemic in…

Author(s): Prem K, Liu Y, Russell TW et al

Lancet Public Health 2020, Published Online March 25, 2020

In December, 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus, emerged in Wuhan, China. The COVID-19…
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Journal article

Digest Author(s): Athena Gogali, MD

Interstitial lung disease is a risk factor for ischaemic heart disease and myocardial infarction.

Author(s): Clarson LE, Bajpai R, Whittle R et al

Heart 2020; 0: 1–7

This is a population-based cohort study that used electronic patient records and aimed to investigate the risk of incident ischaemic heart…
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COVID-19

Journal article

Digest Author(s): Argyris Tzouvelekis, MD

Critical Care Utilization for the COVID-19 Outbreak in Lombardy, Italy

Author(s): Grasselli G, Pesenti A, Cecconi M.

JAMA. Published online March 13, 2020.…

The world has set its eyes on the pandemic crisis of COVID-19. In an elegant commentary recently published in JAMA, authors report the reaction…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a…

Author(s): Zhou F, Yu T, Du R, et al

Lancet Published Online March 9, 2020

Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore

Author(s): Young BE, Xiang Ong SW, Kalimuddin S et al

JAMA. Published online March 03, 2020.…

The authors wanted to report the Singapore experience in regard to SARS CoV-2 infection in Singapore. Epidemiological and clinical data is…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Clinical Characteristics of Coronavirus Disease 2019 in China

Author(s): Guan W, Ni Z, Hu Y et al

NEJM 2020; 10.1056/NEJMoa2002032

This is the first big study which describes the clinical characteristics of coronovirus disease in China. The authors retrieved data from medical…
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COVID-19

Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in…

Author(s): Chen N, Zhou M, Dong X et al

Lancet 2020; 395: 507–13

In December, 2019, a pneumonia associated with the 2019 novel coronavirus (2019-nCoV) emerged in Wuhan, China. This retrospective study aimed to…
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Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Reduced Lung-Cancer Mortality with Volume CT Screening in a Randomized Trial

Author(s): de Koning HJ, van der Aalst CM, de Jong PA et al

N Engl J Med 2020; 382: 503-513

Lung cancer is the leading cause of death from cancer worldwide. A limited number of patients are still alive five years from the initial…
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Journal article

Digest Author(s): Vasileios S Skouras MD

Patient-reported outcomes with durvalumab after chemoradiotherapy in stage III, unresectable…

Author(s): Hui R, Ozgüroğlu M, Villegas A, et al

Lancet Oncol, 2019; 20: 1670–80

The PACIFIC study is an ongoing international, multicentre, randomized controlled trial that compares durvalumab with placebo in unresectable…
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Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Corticosteroid use is not associated with improved outcomes in acute exacerbation of IPF

Author(s): Farrand E, Vittinghoff E, Ley B et al

Respirology 2019; doi: 10.1111/resp.13753

This retrospective study aimed to determine the impact of corticosteroid therapy on in-hospital mortality in acute exacerbation (AE)- IPF…
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Journal article

Digest Author(s): Charalampos Moschos

Final Analysis of a Trial of M72/AS01E Vaccine to Prevent Tuberculosis

Author(s): Dereck R. Tait, Mark Hatherill, Olivier Van Der…

N Engl J Med 2019; 381: 2429-2439

An efficient vaccine is vital for eliminating tuberculosis. The search has been going on for 100 years since the introduction of Bacillus…
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Journal article

Digest Author(s): Sophia E Schiza, MD

Effect of obstructive sleep apnoea and its treatment with continuous positive airway pressure on the…

Author(s): Sánchez-de-la-Torre M, Sánchez-de-la-Torre A,…

Lancet Respir Med. 2019. pii: S2213-2600(19)30271-1

The high prevalence and clinical significance of obstructive sleep apnoea (OSA) as well as its effects on a range of cardiovascular conditions…
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ERS/AIPO Intensive Care corner

Digest Author(s): Silvia Mongodi

Effect of lung recruitment maneuver on oxygenation, physiological parameters and mortality in acute…

Author(s): Pensier J, de Jong A, Hajjej Z, Molinari N, Carr…

Intensive Care Med 2019;45:1691-702

Mechanical ventilation, as the first lifesaving treatment to improve oxygenation in ARDS patients, still presents some challenging aspects for…
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Review

Digest Author(s): Stylianos Loukides, e-Learning Director

EUFOREA consensus on biologics for CRSwNP with or without asthma

Author(s): Wytske J. Fokkens, Valerie Lund, Claus Bachert et…

Allergy 2019; 74: 2312-2319

Type 2 targeting biologics are emerging treatment options for patients with severe asthma. All the currently available biologics have shown…
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Review

Digest Author(s): Stylianos Loukides, e-Learning Director

Sarcoidosis

Author(s): Grunewald J, Grutters JC, Arkema EV et al

Nat Rev Dis Primers 2019; 5: 49

Sarcoidosis is an inflammatory disease characterized by the presence of granulomas in virtually any organ, although the lung is the predominant…
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ERS/AIPO Intensive Care corner

Digest Author(s): Serena Bensai, Lara Pisani

Acute respiratory failure in obesity-hypoventilation syndrome managed in the ICU

Author(s): Chebib N, Nesme P, Freymond N, Argaud L, Rimmelé…

Respir Care 2019. pii: respcare.06901.

Abstract…
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Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Preoperative Evaluation of Patients With Interstitial Lung Disease

Author(s): Patel NM, Kulkarni T, Dilling D et al

Chest. 2019;156: 826-833

Patients with interstitial lung diseases (ILDs) experience an increased risk of postoperative complications (PPCs) or mortality when undergoing…
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Review

Digest Author(s): Stylianos Loukides, e-Learning Director

Acute upper airway obstruction

Author(s): Eskander A, de Almeida JR, Irish JC.

N Engl J Med 2019; 381:1940-1949

Acute upper airway obstruction is a life-threatening clinical condition and requires immediate assessment and intervention. Before treating acute…
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Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Single inhaler extrafine triple therapy in uncontrolled asthma (TRIMARAN and TRIGGER): two…

Author(s): Virchow JC, Kuna P, Paggiaro P et al

Lancet 2019; 394: P1737-1749

Two parallel-group, double-blind, randomised, active-controlled, phase 3 trials (Triple in Asthma With Uncontrolled Patients on Medium Strength…
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ERS/AIPO Intensive Care corner

Digest Author(s): Claudia Crimi

Effect of postextubation high-flow nasal oxygen with noninvasive ventilation vs high-flow nasal…

Author(s): Thille AW, Muller G, Gacouin A, Coudroy R,…

JAMA 2019. [Epub ahead of print]

Timely identification of patients at high risk of extubation failure and implementation of appropriate strategies to prevent post-extubation…
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Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Metoprolol for the Prevention of Acute Exacerbations of COPD

Author(s): Dransfield MT, Voelker H, Bhatt SP et al, Block…

N Engl J Med. 2019; 10.1056/NEJMoa1908142

In the BLOCK COPD (Beta-Blockers for the Prevention of Acute Exacerbations of Chronic Obstructive Pulmonary Disease) trial, the authors wanted to…
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Journal article

Digest Author(s): Athina Trachalaki, Katerina Antoniou -…

Pirfenidone in patients with unclassifiable progressive fibrosing interstitial lung disease: a…

Author(s): Maher TM, Corte TJ, Fischer A et al

Lancet Respir Med 2019;…

The term interstitial lung disease (ILD) includes an enormous amount of parenchymal pulmonary disorders (>200). The appropriate and strict…
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Journal article

Digest Author(s): Athina Trachalaki, Katerina Antoniou -…

Nintedanib in Progressive Fibrosing Interstitial Lung Diseases

Author(s): Flaherty KR, Wells AU, Cottin V et al

N Engl J Med. 2019; doi: 10.1056/NEJMoa1908681

The term interstitial lung disease (ILD) includes an enormous amount of parenchymal pulmonary disorders (>200). The appropriate and strict…
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Guideline

Digest Author(s): Stylianos Loukides, e-Learning Director

Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice…

Author(s): Metlay JP, Waterer GW, Long AC et al

Am J Respir Crit Care Med 2019; 200: e45–e67

The document provides evidence-based guidelines on the management of patients with community-acquired pneumonia. The experts panel addressed 16…
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Review

Digest Author(s): Stylianos Loukides, e-Learning Director

Treatment of Hypertension in Patients with Asthma

Author(s): Christiansen SC and Zuraw BL

N Engl J Med 2019; 381: 1046-57

Asthma and hypertension are common chronic diseases, each with attendant morbidity, mortality, and economic effects.Patients with asthma are more…
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Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Stability of the Blood Eosinophilic Phenotype in Stable and Exacerbated COPD

Author(s): Schumann DM, Tamm M, Kostikas K, Stolz D.

Chest 2019; 156: 456-465

This was an observational multicenter study. 210 patients with stable COPD, GOLD grades II to IV were enrolled. Concordance was defined as blood…
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ERS/AIPO Intensive Care corner

Digest Author(s): Silvia Mongodi

Personalised mechanical ventilation tailored to lung morphology versus low positive end-expiratory…

Author(s): Constantin JM, Jabaudon M, Lefrant JY, Jaber S,…

Lancet Respir Med 2019 . pii: S2213-2600(19)30138-9

In the last years, several studies showed that protective mechanical ventilation with low tidal volume, reduced inspiratory plateau pressure and…
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Journal article

Digest Author(s): Ioannis Vogiatzis, Secretary of Assembly…

Multidisciplinary home-based rehabilitation in inoperable lung cancer: a randomized controlled trial

Author(s): Edbrooke L, Aranda S, Granger C, et al.

Thorax 2019; 74: 787-796

High quality evidence to support the use of rehabilitation in inoperable lung cancer is scarce. The randomized controlled trial by Edbrooke and…
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Journal article

Digest Author(s): Manali Effrosyni, Papiris Spyridon

Bi-allelic missense ABCA3 mutations in a patient with childhood ILD who reached adulthood

Author(s): Manali ED, Legendre M, Nathan N et al

ERJ Open Research 2019 5: 00066-2019

Children’s interstitial lung diseases (chILD) are increasingly recognized and contain many genetic disorders mostly related to rare mutations…
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Journal article

Digest Author(s): Vasileios S. Skouras MD

Local consolidative therapy vs. maintenance therapy or observation for patients with oligometastatic…

Author(s): Gomez DR, Tang C, Zhang J, et al

J Clin Oncol; 37: 1558-65

The study is a multicenter, phase II, randomized trial that included patients with oligometastatic stage IV non-small-cell lung cancer (NSCLC)…
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ERS statement

Digest Author(s): Pierantonio Laveneziana, Secretary…

ERS statement on respiratory muscle testing at rest and during exercise

Author(s): Laveneziana P et al

European Respiratory Journal 2019 53: 1801214

Assessing respiratory muscle function is crucial for clinicians, physiologists and researchers. Several methodological developments over the past…
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Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

C-Reactive Protein Testing to Guide Antibiotic Prescribing for COPD Exacerbations

Author(s): Butler CC, Gillespie D et al

N Engl J Med 2019; 381: 111-120

The study is a multicenter, open-label, randomized, controlled trial involving patients with a diagnosis of COPD in their primary care clinical…
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ERS/AIPO Intensive Care corner

Digest Author(s): Claudia Crimi

Effect of pressure support vs T-Piece ventilation strategies during spontaneous breathing trials on…

Author(s): Subirà C, Hernández G, Vázquez A,…

JAMA 2019; 321:2175-82

Liberation from Mechanical Ventilation (MV) (1-3) represents an important challenge for physicians in Intensive Care Unit (ICU) because…
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ERS/AIPO Intensive Care corner

Digest Author(s): Adriana J. de Grauw, Michela D’Ascanio…

Long-term outcome after prolonged mechanical ventilation: a long-term acute-care hospital study

Author(s): Jubran A, Grant BJ, Duffner LA, Collins EG, Lanuza…

Am J Respir Crit Care Med. 2019;199: 1508-1516

Prognosis of patients requiring prolonged mechanical ventilation is generally perceived to be poor and clinical studies to date have primarily…
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Journal article

Digest Author(s): Katerina Antoniou, Secretary assembly 12

Long-term treatment with recombinant human pentraxin 2 protein in patients with idiopathic pulmonary…

Author(s): Raghu G, van den Blink B, Hamblin MJ et al

Lancet Respir Med. 2019 May 17

Patients with idiopathic pulmonary fibrosis treated with a recombinant human pentraxin 2 protein exhibited sustained reductions in decline of FVC…
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Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Omega-3 and Omega-6 Intake Modifies Asthma Severity and Response to Indoor Air Pollution in Children

Author(s): Brigham EP, Woo H et al

Am J Respir Crit Care Med. 2019; 199: 1478-1486

The study aimed to determine the relationship between omega-3 and omega-6 fatty acid intake and pediatric asthma morbidity Furthermore, to define…
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ERS statement

Digest Author(s): Paraskevi Katsaounou MD

ERS Position Paper on Tobacco Harm Reduction

Author(s): Stylianos Loukides, e-Learning Director on hehalf…

https://www.ersnet.org/the-society/news/ers-tobacco-control-committee-cannot-recommend-tobacco-harm-reduction…

Harm reduction is a tactic (policy, program, practice) that aim primarily to reduce the adverse health, social and economic consequences of the…
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Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Benralizumab for the Prevention of COPD Exacerbations

Author(s): Criner GJ, Celli BR, Brightling CE et al.

N Engl J Med. 2019 May 20. doi: 10.1056/NEJMoa1905248

The current studies named Galathea & Terranova aimed to determine the efficacy and safety of benralizumab, an interleukin-5 receptor…
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Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level

Author(s): Lazarus SC, Krishnan JA, King TS et al.

N Engl J Med. 2019 May 19

In many patients with mild, persistent asthma, eosinophilic inflammation is absent. The proper treatment for these patients remains…
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Journal article

Digest Author(s): Catherine Greene, Secretary Assembly 3

Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant…

Author(s): Dedrick RM, Guerrero-Bustamante CA, Garlena RA et…

Nat Med. 2019 May;25(5): 730-733

A 15 year-old girl with cystic fibrosis (Phe508del homozygous, FEV1 29%) infected with antibiotic-resistant Mycobaterium abscessus subspecies…
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ERS/AIPO Intensive Care corner

Digest Author(s): Silvia Mongodi

Lung ultrasound combined with procalcitonin for a diagnosis of ventilator-associated pneumonia

Author(s): Juandi Zhou, Jia Song, Shijin Gong, Weihang Hu,…

Respiratory Care May 2019, 64 (5) 519-527

Ventilator-Associated Pneumonia (VAP) is the most frequent nosocomial infection in Intensive Care Units (ICU) and is associated with longer ICU…
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Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director

Azithromycin during Acute COPD Exacerbations Requiring Hospitalization (BACE): a Multicentre,…

Author(s): Vermeersch K,Gabrovska M , Aumann J et al on…

Am J Respir Crit Care Med. 2019 May 3. doi:…

In this double- blind placebo-controlled trial the authors extended previous knowledge in the field by administering Azithromycin during and for…
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Journal article

Digest Author(s): Sophia Schiza, Chair of Group 4.02

Long-term clinical effectiveness of continuous positive airway pressure therapy versus non-invasive…

Author(s): Masa JF et al

Lancet. 2019; 393(10182): 1721-1732

This study is a nationwide, multicenter, open-label, randomized controlled trial, contacted between May 2009 to March 2013, included 204…
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Journal article

Digest Author(s): Wouter H. van Geffen

Pembrolizumab versus chemotherapy for previously untreated, PD-L1-expressing, locally advanced or…

Author(s): Mok TSK, Wu YL, Kudaba I et al

Lancet. 2019 Apr 4. pii: S0140-6736(18)32409-7

In a randomised, open-label, controlled, phase 3 trial the anti-programmed death 1 monoclonal antibody pembrolizumab was assessed for previously…
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Journal article

Digest Author(s): Stylianos Loukides, e-Learning Director…

COPD exacerbations: the impact of long versus short courses of oral corticosteroids on mortality and…

Author(s): Sivapalan P et al

BMJ Open Respiratory Research 2019; 6:e000407

The authors performed a nationwide observational cohort study that was based on linked administrative registry data between 1/1/2010 and…
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Tobacco interventions

Digest Author(s): Sylianos Loukides, e-Learning Director…

The WHO e-Learning course Training for primary care providers: brief tobacco interventions

Author(s): ERS Tobacco Control Committee

WHO e-learning course

The WHO e-Learning course “Training for primary care providers: brief tobacco interventions” is converted from Part III of WHO training…
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Lung cancer

Digest Author(s): Wouter H. van Geffen

Pembrolizumab in patients with advanced non-small-cell lung cancer (KEYNOTE-001): 3-year results…

Author(s): Leighl NB, Hellmann MD, Hui R, et al

Lancet Respiratory Medicine 2019;7:347-57.

In a multicohort, open label landmark phase 1 study the anti-programmed death 1 monoclonal antibody pembrolizumab was assessed for advanced or…
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Journal article

Digest Author(s): Sylianos Loukides, e-Learning Director

Pregnancy-adapted YEARS Algorithm for Diagnosis of Suspected Pulmonary Embolism

Author(s): van der Pol LM, Tromeur C, Bistervels IM et al

N Engl J Med 2019; 380: 1139-1149.

In a prospective study involving pregnant women with suspected pulmonary embolism (PE), the authors used clinical based criteria from the…
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ERS/AIPO Intensive Care Corner

Digest Author(s): Marianna Laviola

A physiological study to determine the mechanism of carbon dioxide clearance during apnoea when…

Author(s): Hermez LA, Spence CJ, Payton MJ, Nouraei SAR,…

Anaesthesia. 2019; 74: 441-449

Several studies have shown that in patients who are anaesthetised and apnoeic the use of high-flow nasal oxygenation can increase apnoea time by…
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ERS/AIPO Intensive Care corner

Digest Author(s): Julien Guiot

Intensified Therapy with Inhaled Corticosteroids and Long-Acting β2-Agonists at the Onset of Upper…

Author(s): Daiana Stolz, Hans H. Hirsch, Daniel …

Am J Respir Crit Care Med. 2018; 197: 1136-1146

In chronic obstructive pulmonary diseases (COPD), inhaled corticostéroids (ICS) are associated with side-effects including risk of pneumonia.…
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ERS/AIPO Intensive Care corner

Digest Author(s): Julien Guiot

High-flow nasal cannula oxygen therapy decreases postextubation neuroventilatory drive and work of…

Author(s): Rosa Di mussi, Savino Spadaro, Tania Stripoli,…

Crit Care 2018; 22: 180

Di mussi et al. explores the potential usefulness of high-flow nasal cannula (HFNC) oxygen therapy in the post-extubation phase of patients…
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ERS/AIPO Intensive Care corner

Digest Author(s): Julien Guiot

Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome

Author(s): Alain Combes, David Hajage, Gilles Capellier,…

N Engl J Med 2018; 378: 1965-1975

In the EOLIA trial, Combes et al. evaluates the benefit on 60-day mortality of patients suffering from very severe acute respiratory distress…
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ERS/AIPO Intensive Care corner

Digest Author(s): Claudia Crimi

Effect of High-Flow Nasal Oxygen vs. Standard Oxygen on 28-Day Mortality in Immunocompromised…

Author(s): Azoulay E, Lemiale V, Mokart D, Nseir S, Argaud L,…

JAMA. 2018; 320: 2099-2107

Acute hypoxemic respiratory failure (ARF) is one of the major cause of critical illness in immunocompromized patients. High flow nasal cannula…
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ERS/AIPO Intensive Care corner

Digest Author(s): Daniel López Padilla

Effect of Titrating Positive End-Expiratory Pressure (PEEP) With an Esophageal Pressure–Guided…

Author(s): Jeremy R. Beitler, Todd Sarge, Valerie M.…

JAMA. 2019; doi: 10.1001/jama.2019.0555. [Epub ahead of…

Acute Respiratory Distress Syndrome (ARDS) represents a true challenge for clinicians, giving the well demonstrated harmful effect of high tidal…
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Journal article

Digest Author(s): Sylianos Loukides, e-Learning Director

Aspirin Use and Respiratory Morbidity in COPD

Author(s): Fawzy A, Putcha N, Aaron CP et al

Chest 2019; 155: 519–527

Fawzy and co-authors, using the Spiromics cohort of COPD pateints, published an interesting propensity- score based study where the self-reported…
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